If you love a classic chicken pot pie, you’re in for a treat with this fun twist—Chicken Pot Pie Bubble Up Casserole! This dish combines all the comforting flavors of a traditional pot pie with a unique bubbly biscuit topping, making it both delicious and irresistibly fun to eat. Best of all, it’s ready for the oven in just 15 minutes, making it perfect for a quick and comforting weeknight dinner.

Imagine tender pieces of chicken, creamy sauce, and vibrant mixed vegetables, all topped with buttery, flaky biscuit pieces that “bubble up” as they bake. The result is a golden, bubbly casserole that has all the best parts of a chicken pot pie in every bite. It’s a perfect blend of savory goodness and family-friendly appeal that will have everyone asking for seconds!

Whether you’re looking for a way to use up leftover chicken or just want to switch up your dinner routine, this Chicken Pot Pie Bubble Up Casserole is sure to be a hit. With minimal prep and maximum flavor, it’s an easy meal that delivers comfort and joy with every forkful.

Ingredients that Make This Chicken Pot Pie Bubble Up Casserole Special

Cooked and shredded chicken – Provides the hearty base of this casserole, ensuring every bite is filled with tender protein.
Cream of chicken soup – Adds a creamy texture and rich flavor that binds all the ingredients together.
Sour cream – Enhances the creamy texture while adding a slight tang to balance the savory flavors.
Cheddar cheese, shredded – Brings a cheesy richness to the dish, adding another layer of comfort.
Mixed frozen vegetables – A colorful blend that offers a mix of flavors and a healthy boost.
Garlic powder – Infuses the casserole with a subtle yet delicious garlicky depth.
Seasoned salt – Enhances all the flavors, providing a perfectly balanced seasoning.
Refrigerated biscuits – The star of the show! These pieces “bubble up” to create a flaky, golden topping that’s irresistibly good.

Step-by-Step: How to Whip Up Your Chicken Pot Pie Bubble Up Casserole

Preheat your oven to 375°F to ensure it’s nice and hot when your casserole is ready to bake.
In a medium mixing bowl, blend together the shredded chicken, cream of chicken soup, sour cream, cheddar cheese, mixed veggies, garlic powder, and seasoned salt. Make sure everything is well combined for an even distribution of flavors.
Cut each refrigerated biscuit into quarters, then gently fold them into the chicken mixture, making sure every piece is coated with the creamy sauce.
Lightly grease a 9×13 baking pan with cooking spray and spread the chicken mixture evenly across the pan, ensuring the biscuit pieces are spread out and not clumped together.
Pop the pan into the preheated oven and bake for 35-45 minutes. Keep an eye on it; you’re looking for a golden-brown top and bubbling edges. If needed, bake longer to achieve the desired doneness.
Once the casserole is beautifully golden and cooked through, remove it from the oven, let it cool for a few minutes, and serve hot.

Recipe Tips for the Perfect Bubble Up Casserole

For a richer flavor, consider adding sautéed onions or mushrooms to the chicken mixture.
Use a combination of cheddar and mozzarella for an extra gooey and cheesy casserole.
Make sure to spread the biscuit pieces evenly to avoid any undercooked sections.

Recipe Variations to Try

This Chicken Pot Pie Bubble Up Casserole is highly customizable! Swap the chicken for turkey, especially around the holidays when you have leftovers. You could also experiment with different vegetables—think peas, corn, or green beans. For a bit of heat, add some diced jalapeños or a dash of cayenne pepper.

How to Store Leftovers Deliciously

Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, simply pop a portion into the microwave or back into the oven until warmed through. For longer storage, this casserole freezes well for up to 2 months. Just thaw overnight in the refrigerator and reheat before serving. Enjoy this comforting dish any day of the week!